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Regulation of immune tolerance by anti-inflammatory neuropeptides

Gonzalez-Rey E, Chorny A, Delgado M2007Nature reviews. ImmunologyReview
10.1038/nri1984PubMed
Immune/InnateNeurological

Abstract

The induction of antigen-specific tolerance is essential to maintain immune homeostasis, control autoreactive T cells, prevent the onset of autoimmune diseases and achieve tolerance of transplants. Inflammation is a necessary process for eliminating pathogens, but can lead to serious deleterious effects in the host if left unchecked. Identifying the endogenous factors that control immune tolerance and inflammation is a key goal in the field of immunology. In the last decade, various neuropeptides that are produced by immune cells with potent anti-inflammatory actions were found to participate in the maintenance of tolerance in different immunological disorders.

Cited By (14)

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  • Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptideThe Journal of Immunology · 2009
  • Antimicrobial neuropeptides and their therapeutic potential in vertebrate brain infectious diseaseFrontiers in Immunology · 2024
  • The expression of vasoactive intestinal peptide receptor 1 is negatively modulated by microRNA 525-5pPLoS ONE
  • Antimicrobial Neuropeptides and Their Receptors: Immunoregulator and Therapeutic Targets for Immune Disorders

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    • References (20)

    • Anti-inflammatory actions of the neuroimmunomodulator α-MSHImmunology Today · 1997
    • In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha‐melanocyte stimulating hormone (α‐MSH)Immunology and Cell Biology · 2001
    • The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (α-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophagesJournal of Neuroimmunology · 2005
    • α-Melanocyte-stimulating Hormone Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Production in Leukocytes by Modulating Protein Kinase A, p38 Kinase, and Nuclear Factor κB Signaling PathwaysJournal of Biological Chemistry · 2003
    • Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIPJournal of Leukocyte Biology · 2005
    • Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10The Journal of Immunology · 2004
    • New Insights into the Functions of α‐MSH and Related Peptides in the Immune SystemAnnals of the New York Academy of Sciences · 2003
    • Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microgliaJournal of Leukocyte Biology · 1998
    • Proopiomelanocortin and the immune-neuroendocrine connectionAnnals of the New York Academy of Sciences · 1999
    • The neuropeptide vasoactive intestinal peptide generates tolerogenic dendritic cellsThe Journal of Immunology · 2005
    • Vasoactive intestinal peptide induces CD4+,CD25+ T regulatory cells with therapeutic effect in collagen‐induced arthritisArthritis & Rheumatism · 2006
    • Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitisEuropean Journal of Immunology · 2006
    • Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivoJournal of Leukocyte Biology · 2005
    • Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Enhance IL-10 Production by Murine Macrophages: In Vitro and In Vivo StudiesThe Journal of Immunology · 1999
    • VIP/PACAP oppositely affects immature and mature dendritic cell expression of CD80/CD86 and the stimulatory activity for CD4(+) T cellsJournal of Leukocyte Biology · 2004
    • α -MSH Modulates Experimental Inflammatory Bowel DiseasePeptides · 1997
    • Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammationJournal of Clinical Investigation · 1996
    • The proopiomelanocortin systemAnnals of the New York Academy of Sciences · 1999
    • Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disordersProceedings of the National Academy of Sciences · 2005
    • Induction of regulatory T cells by the immunodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta 2Journal of Leukocyte Biology · 2002