Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitis
Abstract
AbstractCD4+CD25+ regulatory T cells (Treg) control the immune response to a variety of antigens, including self‐antigens. Several models support the idea of the peripheral generation of CD4+CD25+ Treg from CD4+CD25– T cells. Little is known about the endogenous factors and mechanisms controlling the peripheral expansion of CD4+CD25+ Treg. In this study we report on the capacity of the vasoactive intestinal peptide (VIP), an immunosuppressive neuropeptide, to induce functional Treg in vivo during the development of experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. The administration of VIP to EAE mice results in the expansion of the CD4+CD25+, Foxp3‐expressing T cells in the periphery and the nervous system, which inhibit encephalitogenic T cell activation. In addition to the increase in the number of CD4+CD25+ Treg, VIP induces more efficient suppressors on a per cell basis. The VIP‐generated CD4+CD25+ Treg transfer suppression and significantly ameliorate the progression of the disease.
Key Biomarkers
Symptom Clusters
Cited By (8)
- Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitisProceedings of the National Academy of Sciences · 2009
- Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritisCellular Immunology · 2010
- TREGking From Gut to Brain: The Control of Regulatory T Cells Along the Gut-Brain AxisFrontiers in Immunology · 2022
- Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptideThe Journal of Immunology · 2009
- Regulation of immune tolerance by anti-inflammatory neuropeptidesNature reviews. Immunology · 2007
- Emerging roles of vasoactive intestinal peptide: a new approach for autoimmune therapyAnnals of the Rheumatic Diseases · 2007
- Endogenous anti‐inflammatory neuropeptides and pro‐resolving lipid mediators: a new therapeutic approach for immune disorders
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