Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation
Abstract
Alpha-Melanocyte-stimulating hormone (MSH) is a potent anti-inflammatory agent in many models of inflammation, suggesting that it inhibits a critical step common to different forms of inflammation. We showed previously that alpha-MSH inhibits nitric oxide (NO) production in cultured macro-phages. To determine how alpha-MSH acts in vivo, we induced acute hepatic inflammation by administering endotoxin (LPS) to mice pretreated with Corynebacterium parvum, alpha-MSH prevented liver inflammation even when given 30 min after LPS administration. To determine the mechanisms of action of alpha-MSH, we tested its influence on NO, infiltrating inflammatory cells, cytokines, and chemokines. Alpha-MSH inhibited systemic NO production, hepatic neutrophil infiltration, and increased hepatic mRNA abundance for TNF alpha, and the neutrophil and monocyte chemokines (KC/IL-8 and MCP-1). We conclude that alpha-MSH prevents LPS-induced hepatic inflammation by inhibiting production of chemoattractant chemokines which then modulate infiltration of inflammatory cells. Thus, alpha-MSH has an effect very early in the inflammatory cascade.
Cited By (24)
- Targeting melanocortin receptors as a novel strategy to control inflammationPharmacological Reviews · 2004
- Anti-inflammatory actions of the neuroimmunomodulator α-MSHImmunology Today · 1997
- α-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory DiseasesEndocrine Reviews
- In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha‐melanocyte stimulating hormone (α‐MSH)Immunology and Cell Biology · 2001
- α-Melanocyte-stimulating Hormone Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Production in Leukocytes by Modulating Protein Kinase A, p38 Kinase, and Nuclear Factor κB Signaling PathwaysJournal of Biological Chemistry · 2003
- Mechanisms of Antiinflammatory Action of the Neuroimmunomodulatory Peptide α‐MSHAnnals of the New York Academy of Sciences · 1998
Related Papers
- Investigating the effect of a low carbohydrate, high saturated fat diet on concentration levels of markers associated with a leaky gut and the association with glucose homeostasisResearch Square · 2023 · 3 shared tags
- TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injuryInternational Journal of Biological Sciences · 2022 · 3 shared tags
- The gut microbiota2023 · 3 shared tags
- Hesperetin suppresses LPS/high glucose-induced inflammatory responses via TLR/MyD88/NF-κB signaling pathways in THP-1 cellsNutrition Research and Practice · 2021 · 3 shared tags
- Treatable metabolic and inflammatory abnormalities in Post COVID Syndrome (PCS) define the transcriptomic basis for persistent symptoms: Lessons from CIRSMedical Research Archives · 2021 · 3 shared tags
- Newer Molecular Methods Bring New Insights into Human- And Building-Health Risk Assessments from Water-Damaged Buildings: Defining Exposure and Reactivity, the Two Sides of Causation of CIRS-WDB Illness