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INFLUENCE OF ACUTE ADMINISTRATION OF HUMAN GROWTH HORMONE AND ALPHA-MSH ON PLASMA CONCENTRATIONS OF ALDOSTERONE, CORTISOL, CORTICOSTERONE AND GROWTH HORMONE IN MAN

Birkhäuser M., Gaillard R., Riondel A. M. +1 more1975European Journal of EndocrinologyJournal Article
10.1530/acta.0.0790016PubMed
CardiovascularEndocrine (ADH/ACTH/MSH)GastrointestinalHypothalamic-PituitaryImmune/InnateMusculoskeletalNeurologicalOcularRespiratory/Sinus
Bacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsVolatile Organic Compounds (VOCs)Water-Damaged Buildings (WDB)

Abstract

ABSTRACT The effect of acute administration of human growth hormone (HGH) and of alpha-melanocyte stimulating hormone (alpha-MSH) on plasma aldosterone, cortisol, corticosterone and growth hormone has been studied in normal man and in patients with panhypopituitarism. There is no acute effect of exogenous HGH on plasma levels of aldosterone, cortisol and corticosterone in normal man and in patients with panhypopituitarism. The plasma level of immunoreactive HGH measured during acute HGH infusion in man does not seem to be proportional to the doses administered in our study. Alpha-MSH raises the concentration of plasma HGH, but this stimulation is not dose-dependent. Aldosterone, cortisol and corticosterone concentrations are not influenced by the elevation of HGH mediated by alpha-MSH in normal man. Although in some patients with panhypopituitarism an elevation of plasma aldosterone concentration following alpha-MSH infusion is observed, it is unlikely that MSH is directly involved in the acute regulation of aldosterone secretion in healthy subjects.

Key Biomarkers

Alpha Melanocyte Stimulating Hormone (MSH)Immunoglobulin E (IgE)LeptinMatrix Metalloproteinase 9 (MMP9)Vascular Endothelial Growth Factor (VEGF)Visual Contrast Sensitivity (VCS)

Symptom Clusters

Appetite swingsConfusionCoughDifficulty with concentrationExcessive thirstFatigueFrequent urinationHeadacheJoint painLight sensitivityMemory lossMood swingsMuscle achesNight sweatsShortness of breathSinus congestionTingling in extremitiesWord finding difficulty

Cited By (4)

  • Chronic biotoxin-associated illness: Multiple-system symptoms, a vision deficit, and effective treatmentNeurotoxicology and Teratology · 2005
  • Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
  • A time-series study of sick building syndrome: chronic, biotoxin-associated illness from exposure to water-damaged buildingsNeurotoxicology and Teratology · 2005
  • Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammationJournal of Clinical Investigation · 1996

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