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Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide

Robert P. Reynolds, Ran Fan, Aurora Tinajero +7 more2024Molecular MetabolismJournal Article
10.1016/j.molmet.2024.101986PubMedFree full text
Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryImmune/Innate
Bacterial Endotoxins

Abstract

Our data indicate endogenous α-MSH contributes to the inflammatory immune responses triggered by low-dose LPS administration and suggest that targeting the melanocortin system could be a potential therapeutic for the treatment of sepsis or inflammatory disease.

Key Biomarkers

Alpha Melanocyte Stimulating Hormone (MSH)

Cited By (1)

  • Clearance of multiple antibiotic-resistant coagulase-negative staphylococci is selectively associated with higher circulating α-melanocyte stimulating hormone in patients evaluated for chronic inflammatory response syndromeFrontiers in Endocrinology · 2026

References (14)

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  • Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male ratsNeuroendocrinology · 2004
  • A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 MicePLoS ONE · 2013
  • Advances in Anti-obesity Pharmacotherapy: Current Treatments, Emerging Therapies, and ChallengesCureus · 2023

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