Induction of regulatory T cells by the immunodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta 2
Abstract
AbstractRecently, we have reported that the cytokines α-melanocyte-stimulating hormone (α-MSH) and transforming growth factor-β2 (TGF-β2) work in synergy to induce the activation of regulatory T (Treg) cells. When we used α-MSH and TGF-β2 to generate ocular autoantigen-specific Treg cells and adoptively transferred them into mice susceptible to experimental autoimmune uveoretinitis (EAU), there was suppression in the incidence and severity of EAU. Specificity to a retinal autoantigen was required for the Treg cells to suppress EAU. When stimulated, these Treg cells produced TGF-β1, and their production of interferon-γ, interleukin (IL)-10, and IL-4 was suppressed. Also, the Treg cells are suppressed in their proliferative response. Our results demonstrate that α-MSH with TGF-β2 induce Treg cells that can subdue a tissue-specific autoimmune response. This also promotes the possibility of using these immunomodulating cytokines to purposely induce antigen-specific Treg cells to prevent and suppress autoimmune disease.
Key Biomarkers
Symptom Clusters
Cited By (15)
- α-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory DiseasesEndocrine Reviews
- The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (α-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophagesJournal of Neuroimmunology · 2005
- Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
- The intricate interface between immune system and metabolismTrends in Immunology · 2004
- Ocular Vascular Diseases: From Retinal Immune Privilege to InflammationInternational Journal of Molecular Sciences · 2023
- Endogenous Cortisol and TGF-β in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell FunctionThe Journal of Immunology · 2011
Related Papers
- Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarumEnvironmental Health Perspectives · 2004 · 15 shared tags
- Correction to “Maitotoxin induces biphasic interleukin-1β secretion and membrane blebbing in murine macrophages”Mol Pharmacol · 2004 · 15 shared tags
- HUMAN VISUAL FUNCTION IN THE NORTH CAROLINA CLINICAL STUDYON POSSIBLE ESTUARY-ASSOCIATED SYNDROMEJournal of Toxicology and Environmental Health · 2001 · 15 shared tags
- Cholestyramine protection against ochratoxin A toxicity: role of ochratoxin A sorption by the resin and bile acid enterohepatic circulationJournal of Food Protection · 1999 · 15 shared tags
- In vitro and in vivo studies to assess the effectiveness of cholestyramine as a binding agent for fumonisinsMycopathologia · 2001 · 15 shared tags
- Occurrence of Toxigenic Aspergillus versicolor Isolates and Sterigmatocystin in Carpet Dust from Damp Indoor EnvironmentsApplied and Environmental Microbiology · 2002 ·