Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis
Tat Fong Ng, Ambika Manhapra, David Cluckey +3 more2021Ocular Immunology and InflammationJournal Article
Hypothalamic-PituitaryImmune/InnateOcular
Abstract
α-MSH treatment of EAU mediates a MC5r-dependent recovery of RPE suppression of phagolysosome activation in macrophages possibly altering antigen processing and presentation. Also, MC5r-expression helps protect the retina from inflammatory damage. In addition, MC5r-expression is important in the homeostatic maintenance of phagosome-maturation within macrophages.
Part of CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Cited By (7)
- The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal ImmunobiologyFrontiers in Immunology · 2021
- Stimulating the Melanocortin System in Uveitis and Diabetes Preserves the Structure and Anti-Inflammatory Activity of the RetinaInternational Journal of Molecular Sciences · 2023
- Ocular immune privilege and retinal pigment epithelial cellsJournal of Leukocyte Biology · 2023
- Melanocortin/MC5R axis regulates the proliferation of hematopoietic stem cells in mice after ionizing radiation injuryBlood Advances · 2023
- The multifunctional human ocular melanocortin systemProgress in Retinal and Eye Research · 2023
- Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and DiseasesDiseases · 2025
- The Therapeutic Effects of Purified Cortrophin Gel on Experimental Autoimmune UveitisOcular Immunology and Inflammation · 2025
References (6)
- In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha‐melanocyte stimulating hormone (α‐MSH)Immunology and Cell Biology · 2001
- Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humorCurrent Eye Research · 1992
- Ocular immunosuppressive microenvironmentChemical immunology and allergy · 2007
- Neuropeptide Regulation of Immunity: The Immunosuppressive Activity of Alpha‐Melanocyte‐Stimulating Hormone (α‐MSH)Annals of the New York Academy of Sciences · 2000
- Evolution of POMC: origin, phylogeny, posttranslational processing, and the melanocortinsAnnals of the New York Academy of Sciences · 2011
- Induction of regulatory T cells by the immunodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta 2Journal of Leukocyte Biology · 2002
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