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Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis

Tat Fong Ng, Ambika Manhapra, David Cluckey +3 more2021Ocular Immunology and InflammationJournal Article
10.1080/09273948.2020.1849735PubMedFree full text
Hypothalamic-PituitaryImmune/InnateOcular

Abstract

α-MSH treatment of EAU mediates a MC5r-dependent recovery of RPE suppression of phagolysosome activation in macrophages possibly altering antigen processing and presentation. Also, MC5r-expression helps protect the retina from inflammatory damage. In addition, MC5r-expression is important in the homeostatic maintenance of phagosome-maturation within macrophages.

Key Biomarkers

Alpha Melanocyte Stimulating Hormone (MSH)

Cited By (7)

  • The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal ImmunobiologyFrontiers in Immunology · 2021
  • Stimulating the Melanocortin System in Uveitis and Diabetes Preserves the Structure and Anti-Inflammatory Activity of the RetinaInternational Journal of Molecular Sciences · 2023
  • Ocular immune privilege and retinal pigment epithelial cellsJournal of Leukocyte Biology · 2023
  • Melanocortin/MC5R axis regulates the proliferation of hematopoietic stem cells in mice after ionizing radiation injuryBlood Advances · 2023
  • The multifunctional human ocular melanocortin systemProgress in Retinal and Eye Research · 2023
  • Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and DiseasesDiseases · 2025
  • The Therapeutic Effects of Purified Cortrophin Gel on Experimental Autoimmune Uveitis

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References (6)

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  • Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humorCurrent Eye Research · 1992
  • Ocular immunosuppressive microenvironmentChemical immunology and allergy · 2007
  • Neuropeptide Regulation of Immunity: The Immunosuppressive Activity of Alpha‐Melanocyte‐Stimulating Hormone (α‐MSH)Annals of the New York Academy of Sciences · 2000
  • Evolution of POMC: origin, phylogeny, posttranslational processing, and the melanocortinsAnnals of the New York Academy of Sciences · 2011
  • Induction of regulatory T cells by the immunodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta 2Journal of Leukocyte Biology · 2002
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