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The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (α-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages

Taylor AW2005Journal of NeuroimmunologyJournal Article
10.1016/j.jneuroim.2005.01.008PubMed
CardiovascularEndocrine (ADH/ACTH/MSH)GastrointestinalHypothalamic-PituitaryImmune/InnateMusculoskeletalNeurologicalOcularRespiratory/Sinus
Bacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsVolatile Organic Compounds (VOCs)Water-Damaged Buildings (WDB)

Abstract

Since alpha-MSH suppresses endotoxin-induced inflammation by innate immunity, it is possible that alpha-MSH can suppress the interface between innate and adaptive immunity mediated by TLR4-stimulated macrophages. Endotoxin-stimulated macrophages treated with alpha-MSH are suppressed in nitric oxide and IL-12p70 production, and cannot enhance antigen-stimulated IFN-gamma production by Th1 cells. In macrophages treated with alpha-MSH, the inhibitory molecule IRAK-M is bound to IRAK-1, the proximal intracellular signal molecule of endotoxin-bound TLR4. These results further demonstrate the dynamic contribution of the nervous system, and the role of alpha-MSH in modulating the innate and adaptive immune interface in an inflammatory response.

Key Biomarkers

alpha-MSHIFN-γIL-12p70IRAK-1IRAK-MNitric oxideTLR4

Symptom Clusters

Appetite swingsChronic painConfusionCoughDifficulty with concentrationExcessive thirstFatigueFrequent urinationHeadacheIce pick painJoint painLight sensitivityMemory lossMood swingsMuscle achesNight sweatsShortness of breathSinus congestionTingling in extremitiesWord finding difficulty

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  • Ocular immune privilege and retinal pigment epithelial cellsJournal of Leukocyte Biology · 2023
  • Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous InflammationLung · 2022
  • The melanocortin system in control of inflammation

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    • References (7)

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