Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation
Abdolrazagh Hashemi Shahraki, Runxia Tian, Chongxu Zhang +3 more2022LungJournal Article
Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryImmune/InnateRespiratory/Sinus
Abstract
Our results confirm the direct role of type I IFNs in the pathogenesis of sarcoid lung granulomas and highlight α-MSH as a potential novel therapeutic agent for treating pulmonary sarcoidosis.
Key Biomarkers
Alpha Melanocyte Stimulating Hormone (MSH)
References (3)
- The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (α-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophagesJournal of Neuroimmunology · 2005
- α-Melanocyte-stimulating Hormone Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Production in Leukocytes by Modulating Protein Kinase A, p38 Kinase, and Nuclear Factor κB Signaling PathwaysJournal of Biological Chemistry · 2003
- Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agentsThe Journal of Immunology · 1998
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