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Toll-like receptors and innate immunity

Medzhitov R2001Nature reviews. ImmunologyReview
10.1038/35100529PubMed
Immune/Innate

Abstract

Toll-like receptors have a crucial role in the detection of microbial infection in mammals and insects. In mammals, these receptors have evolved to recognize conserved products unique to microbial metabolism. This specificity allows the Toll proteins to detect the presence of infection and to induce activation of inflammatory and antimicrobial innate immune responses. Recognition of microbial products by Toll-like receptors expressed on dendritic cells triggers functional maturation of dendritic cells and leads to initiation of antigen-specific adaptive immune responses.

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  • Vibrio vulnificus: Disease and PathogenesisInfection and Immunity · 2009
  • Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammationNature Immunology · 2004
  • Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and Pathobiology

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