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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil G, Shargill N, Spiegelman B1993ScienceJournal Article
10.1126/science.7678183PubMed
Endocrine (ADH/ACTH/MSH)Immune/Innate

Abstract

Tumor necrosis factor-α (TNF-α) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-α messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-α protein was also elevated locally and systemically. Neutralization of TNF-α in obese fa / fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. These results indicate a role for TNF-α in obesity and particularly in the insulin resistance and diabetes that often accompany obesity.

Key Biomarkers

TNF-α

Symptom Clusters

DiabetesInsulin resistanceObesity

Cited By (44)

  • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistanceAmerican Journal of Physiology-Endocrinology and Metabolism · 2001
  • Adipose Tissue as an Endocrine OrganTrends in Endocrinology and Metabolism · 2000
  • Release of Interleukins and Other Inflammatory Cytokines by Human Adipose Tissue Is Enhanced in Obesity and Primarily due to the Nonfat CellsVitamins and hormones · 2006
  • COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and MortalityFrontiers in Immunology · 2021
  • The Role of the Adipokine Leptin in Immune Cell Function in Health and DiseaseFrontiers in Immunology · 2021
  • Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver CancerInternational Journal of Molecular Sciences · 2021
  • Fish oil attenuates the expression of the CCL2 chemokine and histone-modifying enzymes in LPS-stimulated human preadipocytes

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    • References (2)

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