Adipose Tissue as an Endocrine Organ
Abstract
The discovery of leptin in the mid-1990s has focused attention on the role of proteins secreted by adipose tissue. Leptin has profound effects on appetite and energy balance, and is also involved in the regulation of neuroendocrine and immune function. Sex steroid and glucocorticoid metabolism in adipose tissue has been implicated as a determinant of body fat distribution and cardiovascular risk. Other adipose products, for example, proinflammatory cytokines, complement factors and components of the coagulation/fibrinolytic cascade, may mediate the metabolic and cardiovascular complications associated with obesity.
Part of Endotoxins research, Mold & water-damaged buildings research, Mycotoxins research, CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Symptom Clusters
Cited By (5)
- Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
- Resolvin D1 reduces inflammation in co-cultures of primary human macrophages and adipocytes by triggering macrophagesProstaglandins Leukotrienes and Essential Fatty Acids · 2021
- IL-1β and TNFα Cooperativity in Regulating IL-6 Expression in Adipocytes Depends on CREB Binding and H3K14 AcetylationCells · 2021
- How to modulate inflammatory cytokines in liver diseasesLiver International · 2006
- Cytokines secreted from adipose tissues mediate tumor proliferation and metastasis in triple negative breast cancerBMC Cancer · 2022
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