The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters
Ewelina Maculewicz, B. Antkowiak, Oktawiusz Antkowiak +11 more2022BMC GenomicsJournal Article
Endocrine (ADH/ACTH/MSH)Immune/Innate
Abstract
This study further confirmed that IL-1 family genes are involved in genetic background of obesity. It has been shown that interaction IL1B × IL1RN was associated with both BMI and fat % with rare T allele protecting form higher values. Thus, even if certain polymorphisms in single genes of IL-1 family cannot be defined as related to obesity in examined population, the genetic interrelationships should be analyzed.
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