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Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus

Nanthini Jayabalan, Soumyalekshmi Nair, Andrew Lai +10 more2025Cardiovascular DiabetologyJournal Article
10.1186/s12933-025-02739-zPubMedFree full text
Endocrine (ADH/ACTH/MSH)

Abstract

miR-515-5p, specifically encapsulated within EVs from omental adipose tissue in GDM, regulates placental nutrient uptake, glucose homeostasis, and fetal growth.

References (2)

  • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistanceAmerican Journal of Physiology-Endocrinology and Metabolism · 2001
  • Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceScience · 1993

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