Stachybotrys chartarum: cause of human disease or media darling?
Abstract
This is a review of the literature of associations of the saprotrophic fungus Stachybotrys chartarum sensu lato with human and animal illnesses. This fungus grows on very wet cellulose-based building materials. S. chartarum has been the subject of considerable media attention because of temporal associations of exposure with unexpected and dramatic outcomes such as infant pulmonary hemosiderosis and neurocognitive damage. It is generally accepted that living or working in mouldy environments is associated with building related asthma, exacerbating asthma in mould-sensitive asthmatics and increased rates of upper respiratory disease. However, such relationships are with building-associated moulds, comprising many species that colonize wet or damp building materials, and are not specific to S. chartarum. There is limited evidence that severe lung damage can occur from building exposure to S. chartarum but possibly only under conditions of exposure that approach those associated with handling contaminated straw. There is no positive evidence in the literature to account for putative neurological damage resulting from exposure to this mould.
Part of Mold & water-damaged buildings research, Mycotoxins research · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Symptom Clusters
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References (16)
- Fungal Fragments as Indoor Air BiocontaminantsApplied and Environmental Microbiology · 2002
- Reduction of Pulmonary Toxicity of Stachybotrys chartarum Spores by Methanol Extraction of MycotoxinsApplied and Environmental Microbiology · 2000
- Characterization of Stachybotrys from Water-Damaged Buildings Based on Morphology, Growth, and Metabolite ProductionMycologia · 2002
- Effects of Intranasal Exposure to Spores of Stachybotrys atra in MiceToxicological Sciences · 1997
- Localization of Satratoxin-G in Stachybotrys chartarum Spores and Spore-Impacted Mouse Lung Using ImmunocytochemistryToxicologic Pathology · 2004
- Clinical experience and results of a sentinel health investigation related to indoor fungal exposureEnvironmental Health Perspectives · 1999
- Microanatomical Changes in Alveolar Type II Cells in Juvenile Mice Intratracheally Exposed to Stachybotrys chartarum Spores and ToxinToxicological Sciences · 2002
- Environmental Risk Factors Associated With Pediatric Idiopathic Pulmonary Hemorrhage and Hemosiderosis in a Cleveland CommunityPEDIATRICS · 1997
- Trichothecene mycotoxins in aerosolized conidia of Stachybotrys atraApplied and Environmental Microbiology · 1987
- Overview of investigations into pulmonary hemorrhage among infants in Cleveland, OhioEnvironmental Health Perspectives · 1999
- Comparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strainsToxicological Sciences · 2004
- Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarumMycopathologia · 2002
- The time course of responses to intratracheally instilled toxic Stachybotrys chartarum spores in ratsMycopathologia · 2000
- Airborne outbreak of trichothecene toxicosisAtmospheric Environment (1967) · 1986
- Acute inhalation toxicity of T-2 mycotoxin in mice*1Fundamental and Applied Toxicology · 1987
- Analysis of pulmonary surfactant by fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) sporesChemistry and Physics of Lipids · 2001
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