Sequential upregulation of innate immune responses during acute acquisition of illness in patients exposed prospectively to water-damaged buildings. ASTMH, Philadelphia, PA
CardiovascularEndocrine (ADH/ACTH/MSH)GastrointestinalHematologicalHypothalamic-PituitaryImmune/InnateNeurologicalRespiratory/Sinus
Bacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsWater-Damaged Buildings (WDB)
Abstract
Key Biomarkers
ACTH/cortisolADH/osmolalityAnticardiolipin antibodies (ACLA)Antigliadin antibodies (AGA)C4aHLA DR haplotypesMARCoNSMMP9MR spectroscopy (lactate, G/G ratio)MSHTGF beta-1VEGFVIPVisual Contrast Sensitivity (VCS)von Willebrand Factor (vWF)
Symptom Clusters
Capillary hypoperfusionCognitive dysfunctionEpistaxisHemoptysisMulti-system, multi-symptom illnessNeurologic symptoms
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