Treg cell numbers and function in patients with antibiotic‐refractory or antibiotic‐responsive lyme arthritis

Shen S, Shin J, McHugh G +4 more2010Arthritis & RheumatismJournal Article

Immune/InnateMusculoskeletal

Lyme & Co-Infections

Abstract

, 250; Text, 4,168 O 2010 American College of Rheumatology Received: Nov 25, 2009; Revised: Jan 15, 201 0; Accepted: Mar 17, 201 0 Page 25 of 76 Arthritis & Rheumatism Objective. In a murine model of antibiotic-refractory Lyme arthritis, the numbers of T regulatory cells (Treg) are dramatically reduced. Our goal was to examine Treg numbers and function in human patients with antibiotic-refractory Lyme arthritis.

Cited By (3)

Association of a Toll‐like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic‐refractory Lyme arthritisArthritis & Rheumatism · 2012
A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme diseaseArthritis & Rheumatism · 2013
Dysregulation of CD4+CD25high T Cells in the Synovial Fluid of Patients With Antibiotic‐Refractory Lyme ArthritisArthritis & Rheumatism · 2013

References (8)

Prospective Study of Serologic Tests for Lyme DiseaseClinical Infectious Diseases · 2000
High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic‐refractory lyme arthritisArthritis & Rheumatism · 2007
HLA–DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self‐perpetuating arthritisArthritis & Rheumatism · 2009