← Explorer/Network

Elucidation of Lyme arthritis

Steere AC, Glickstein L2004Nature reviews. ImmunologyReview
10.1038/nri1267PubMed
Immune/InnateMusculoskeletal
Lyme & Co-Infections

Abstract

Before the first description of Lyme arthritis in 1976, patients with this disease were often thought to have juvenile or adult rheumatoid arthritis. It is now known that Lyme arthritis is caused by a tick-borne spirochete that disseminates to joints, where it induces marked pro-inflammatory responses. In most patients, the arthritis resolves with antibiotic treatment. However, in the United States, about 10% of patients with Lyme arthritis develop persistent synovitis, which lasts for months or even several years after the apparent eradication of the spirochete from the joint with antibiotic therapy. The elucidation of Lyme arthritis, from acute infection to chronic synovitis, might help in our understanding not only of this entity, but also of other forms of chronic inflammatory arthritis, including rheumatoid arthritis.

Cited By (12)

  • Association of a Toll‐like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic‐refractory Lyme arthritisArthritis & Rheumatism · 2012
  • A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme diseaseArthritis & Rheumatism · 2013
  • Dysregulation of CD4+CD25high T Cells in the Synovial Fluid of Patients With Antibiotic‐Refractory Lyme ArthritisArthritis & Rheumatism · 2013
  • High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic‐refractory lyme arthritisArthritis & Rheumatism · 2007
  • HLA–DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self‐perpetuating arthritisArthritis & Rheumatism · 2009
  • Chronic Lyme disease: a reviewInfectious Disease Clinics of North America · 2008
  • Induction of Host Matrix Metalloproteinases byBorrelia burgdorferiDiffers in Human and Murine Lyme Arthritis

Related Papers

  • Neuroplasticity Intervention, Amygdala and Insula Retraining (AIR), Significantly Improves Overall Health and Functioning Across Various Chronic Conditions.PubMed · 2023 · 3 shared tags
  • Autism Spectrum Disorders and Lyme Disease: Exploring Shared Neuro-Inflammatory and Immune PathwaysMedical Research Archives · 2025 · 3 shared tags
  • Epidemiology of human babesiosis on Nantucket IslandAmerican Journal of Tropical Medicine and Hygiene · 1981 · 3 shared tags
  • Human Babesiosis on Nantucket IslandAnnals of Internal Medicine · 1977 · 3 shared tags
  • Do babesiosis and malaria share a common disease processAnnals of Tropical Medicine and Parasitology · 1998 · 3 shared tags
  • Increased Arthritis Severity in Mice Coinfected withBorrelia burgdorferiandBabesia microtiThe Journal of Infectious Diseases · 2002 · 3 shared tags
Infection and Immunity · 2005
  • Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritisMolecular & Cellular Proteomics · 2010
  • Lyme Arthritis: Pathogenesis, Clinical Presentation, and ManagementInfectious Disease Clinics of North America · 2008
  • Treg cell numbers and function in patients with antibiotic‐refractory or antibiotic‐responsive lyme arthritisArthritis & Rheumatism · 2010
  • Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint diseaseArthritis Research & Therapy · 2004
  • Clonal diversification in OspA-specific antibodies from peripheral circulation of a chronic Lyme arthritis patientJournal of Immunological Methods · 2007

    • References (15)

    • Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferiInfection and Immunity · 1993
    • Immune Complexes and the Evolution of Lyme ArthritisNew England Journal of Medicine · 1979
    • Correlation of Serum and Cryoglobulin IgM with Activity, and Serum IgG with RemissionArthritis & Rheumatism · 1979
    • An epidemic of oligoarticular arthritis in children and adults in three connecticut communitiesArthritis & Rheumatism · 1977
    • Dual Role of Interleukin-10 in Murine Lyme Disease: Regulation of Arthritis Severity and Host DefenseInfection and Immunity · 1999
    • Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme diseaseInfection and Immunity · 1995
    • Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritisNew England Journal of Medicine · 1994
    • In vitro and in vivo induction of tumor necrosis factor alpha by Borrelia burgdorferiInfection and Immunity · 1992
    • Four Clones of Borrelia burgdorferi Sensu Stricto Cause Invasive Infection in HumansInfection and Immunity · 1999
    • Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient miceNature Medicine · 2002
    • Toll-Like Receptor 2 Is Required for Innate, But Not Acquired, Host Defense to Borrelia burgdorferiThe Journal of Immunology · 2002
    • TREATMENT OF LATE LYME BORRELIOSIS—RANDOMISED COMPARISON OF CEFTRIAXONE AND PENICILLINThe Lancet · 1988
    • The clinical evolution of Lyme arthritisAnnals of Internal Medicine · 1987
    • Genetic control of experimental lyme arthritis in the absence of specific immunityInfection and Immunity · 1999
    • The spirochetal etiology of Lyme diseaseNew England Journal of Medicine · 1983