Dysregulation of CD4+CD25high T Cells in the Synovial Fluid of Patients With Antibiotic‐Refractory Lyme Arthritis

Abstract

243 Full Length Arthritis & Rheumatism DOI 10.1002/art.37910 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an ‘Accepted Article’, doi: 10.1002/art.37910 © 2013 American College of Rheumatology Received: Oct 17, 2012; Accepted: Feb 14, 2013 2 Objective. To explore the role of immune dysregulation in antibiotic-refractory Lyme arthritis, the phenotype, frequency and function of CD4+ Teff and Treg cells were compared in patients with antibiotic-responsive or antibiotic-refractory arthritis. In the latter condition, infection- induced autoimmunity is thought to have a pathogenic role.

Key Biomarkers

Symptom Clusters