A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease
Abstract
249 words Full Length Arthritis & Rheumatism DOI 10.1002/art.37732 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an ‘Accepted Article’, doi: 10.1002/art.37732 © 2012 American College of Rheumatology Received: May 28, 2012; Revised: Aug 19, 2012; Accepted: Sep 27, 2012 2 Abstract Objective. Autoantigen presentation by HLA-DR molecules is thought to be a central component of many autoimmune diseases, but uncovering disease-relevant autoantigens has been a difficult challenge. Our goal was to identify autoantigens in patients with antibiotic- refractory Lyme arthritis, which is thought to result from infection-induced autoimmunity.
Key Biomarkers
Symptom Clusters
References (7)
- Association of a Toll‐like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic‐refractory Lyme arthritisArthritis & Rheumatism · 2012
- High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic‐refractory lyme arthritisArthritis & Rheumatism · 2007
- Proinflammatory mediator-induced reversal of CD4+CD25+ regulatory T cell-mediated suppression in rheumatoid arthritisArthritis & Rheumatism · 2007
- Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritisMolecular & Cellular Proteomics · 2010
- Treg cell numbers and function in patients with antibiotic‐refractory or antibiotic‐responsive lyme arthritisArthritis & Rheumatism · 2010
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