The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
Abstract
The function of regulatory T cells (T(reg) cells) has been attributed to a growing number of diverse pathways, molecules and processes. Seemingly contradictory conclusions regarding the mechanisms underlying T(reg) cell suppressive activity have revitalized skeptics in the field who challenge the core validity of the idea of T(reg) cells as central immune regulators. However, we note that a consensus may be emerging from the data: that multiple T(reg) cell functions act either directly or indirectly at the site of antigen presentation to create a regulatory milieu that promotes bystander suppression and infectious tolerance. Thus, the versatility and adaptability of the Foxp3+ T(reg) cells may in fact be the best argument that these cells are 'multitalented masters of immune regulation'.
Key Biomarkers
Cited By (14)
- How regulatory T cells workNature reviews. Immunology · 2009
- CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection ModelImmunity · 2011
- Regulatory T cells and inhibitory cytokines in autoimmunityCurrent Opinion in Immunology · 2009
- Altered expression of CD4+CD25+ regulatory T cells and its 5-HT1a receptor in patients with major depression disorderJournal of Affective Disorders · 2010
- All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitisJournal of Leukocyte Biology · 2009
- Decreased FOXP3 expression in small airways of smokers with COPDEuropean Respiratory Journal · 2009
- Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis
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