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CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

Pandiyan P, Conti HR, Zheng L +6 more2011ImmunityJournal Article
10.1016/j.immuni.2011.03.002PubMedFree full text
GastrointestinalImmune/Innate
Indoor Mold (Stachybotrys, Aspergillus, etc.)

Abstract

Th17 cells and CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells are thought to promote and suppress inflammatory responses, respectively. Here we explore why under Th17 cell polarizing conditions, Treg cells did not suppress, but rather upregulated, the expression of interleukin-17A (IL-17A), IL-17F, and IL-22 from responding CD4(+) T cells (Tresp cells). Upregulation of IL-17 cytokines in Tresp cells was dependent on consumption of IL-2 by Treg cells, especially at early time points both in vitro and in vivo. During an oral Candida albicans infection in mice, Treg cells induced IL-17 cytokines in Tresp cells, which markedly enhanced fungal clearance and recovery from infection. These findings show how Treg cells can promote acute Th17 cell responses to suppress mucosal fungus infections and reveal that Treg cells have a powerful capability to fight infections besides their role in maintaining tolerance or immune homeostasis.

Key Biomarkers

CD4+CD25+Foxp3+IL-17AIL-17FIL-22Th17 cells

Symptom Clusters

Mucosal fungal infectionOral candidiasis

Cited By (5)

  • Foxp3+ regulatory T cells, immune stimulation and host defence against infectionImmunology · 2012
  • T helper 17 cell heterogeneity and pathogenicity in autoimmune diseaseTrends in Immunology · 2011
  • From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokinesNature Immunology · 2012
  • Il-17 signaling in host defense against Candida albicansImmunologic Research · 2011
  • “Molding” immunity—modulation of mucosal and systemic immunity by the intestinal mycobiome in health and diseaseMucosal Immunology · 2022

References (2)

  • The Foxp3+ regulatory T cell: a jack of all trades, master of regulationNature Immunology · 2008
  • IL-17 and Th17 cellsAnnual Review of Immunology · 2009

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