Neuropsychological performance of patients following mold exposure
Abstract
UNLABELLED: This study investigated the effects of mold exposure (ME) on human cognition by analyzing neuropsychological data from patients who were exposed to mold in their homes or workplaces. Compared to normative data, ME patients were impaired (<10th percentile) on a number of cognitive measures, with the most consistent deficits in visuospatial learning, visuospatial memory, verbal learning, and psychomotor speed. We also examined emotional functioning and found that a number of ME patients showed evidence of both Axis I and Axis II pathology. Interestingly, there was a significant correlation among patients' scores on the Beck Depression Inventory-Second Edition and the number of neuropsychological tests falling within the impaired range. Given the limited understanding of ME and its effect on the human central nervous system, we provide a working model that attempts to capture the complex interactions of impaired cognition, psychosocial stressors, poor physical health, and emotional functioning in patients following ME. KEYWORDS: mold exposure, mild traumatic brain injury, toxic exposure
Part of Mold & water-damaged buildings research, Mycotoxins research · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Symptom Clusters
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References (4)
- Building-Associated Pulmonary Disease From Exposure toStachybotrys chartarum and Aspergillus versicolorJournal of Occupational and Environmental Medicine · 1998
- Stachybotrys, a Mycotoxin-Producing Fungus of Increasing Toxicologic ImportanceJournal of Toxicology Clinical Toxicology · 1998
- Toxigenic fungi in a water-damaged building: an intervention studyAmerican Journal of Industrial Medicine · 1998
- Tremorgenic encephalopathy: a role of mycotoxins in the production of CNS disease in humansCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 1993
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