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Erythropoietin as an antiapoptotic, tissue-protective cytokine

Ghezzi P, Brines M2004Cell Death and DifferentiationReview
10.1038/sj.cdd.4401450PubMedFree full text
Neurological

Abstract

Erythropoietin (EPO) increases the number of circulating erythrocytes primarily by preventing apoptosis of erythroid progenitors. In addition to this proerythroid action, results of recent studies show that systemically administered EPO is protective in vivo, in several animal models of neuronal injury. In vitro, EPO prevents neuronal apoptosis induced by a variety of stimuli. This review summarizes the neuroprotective actions of EPO and discusses the underlying mechanisms in terms of signal transduction pathways involved. The understanding of these mechanisms will help differentiate the neuroprotective actions of EPO from its role in the bone marrow.

Key Biomarkers

Erythropoietin (EPO)

Symptom Clusters

Antiapoptotic effectsNeuroprotection

Cited By (4)

  • Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injuryThe FASEB Journal · 2005
  • Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathyEuropean Heart Journal · 2006
  • Modulation of immune response by head injuryInjury · 2007
  • Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injuryProceedings of the National Academy of Sciences · 2005

References (15)

  • Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosisThe Journal of Experimental Medicine · 2003
  • Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up‐regulating Bcl‐xL expressionJournal of Neuroscience Research · 2002

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