Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro
Abstract
Recently, we have reported that erythropoietin (Epo) provides neuroprotection in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-induced neurotoxicity in vivo. In the present study, we investigated the effects of single Epo administration on brain antioxidant enzyme (superoxide dismutase (SOD) and glutathion peroxidase (GSHPx)) activities in this model in C57BL/6 mice. We found that MPTP treatment decreased GSHPx activity in both substantia nigra and striatum, and Epo restores nigral GSHPx activity decreased by MPTP. SOD enzyme activity was not significantly changed by MPTP and Epo treatment. Further, Epo stimulated astroglial GSHPx production in neonatal murine astroglial cell culture suggesting that the possible cell source for the stimulation of GSHPx activity by Epo in the MPTP-induced neurotoxicity model are astroglia. In conclusion, modulation of the astroglial antioxidant defense system might be one of the mechanisms by which Epo exerts a beneficial effect in MPTP-induced Parkinsonism.
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Cited By (9)
- Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cellsEuropean Journal of Pharmacology · 2007
- Erythropoietin as an antiapoptotic, tissue-protective cytokineCell Death and Differentiation · 2004
- HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated miceMolecular Therapy · 2006
- Erythropoietin and the nervous systemBrain Research · 2004
- Beneficial and ominous aspects of the pleiotropic action of erythropoietinAnnals of Hematology · 2004
- Erythropoietin: novel approaches to neuroprotection in human brain diseaseMetabolic Brain Disease · 2004
- Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson’s diseaseNeuroscience · 2007
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