Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production
Abstract
Erythropoietin (EPO), produced by the kidney and fetal liver, is a cytokine-hormone that stimulates erythropoiesis under hypoxic conditions. It has been shown that EPO is produced in the central nervous system and its receptor is expressed on neurons. Since EPO has neuroprotective effects in vitro and in vivo against brain injury, we investigated the effect of EPO treatment on locomotor activities of animals, survival of nigral dopaminergic neurons and nitrate levels in substantia nigra and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinsonism in C57/BL mice. Our findings suggest that EPO has protective and treating effect in MPTP-induced neurotoxicity in this mouse model of Parkinson's Disease via increasing nitric oxide production.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Cited By (14)
- Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injuryThe FASEB Journal · 2005
- Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cellsEuropean Journal of Pharmacology · 2007
- Erythropoietin as an antiapoptotic, tissue-protective cytokineCell Death and Differentiation · 2004
- HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated miceMolecular Therapy · 2006
- Erythropoietin and the nervous systemBrain Research · 2004
- Beneficial and ominous aspects of the pleiotropic action of erythropoietinAnnals of Hematology · 2004
- Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitroNeuroscience Letters · 2002
- Erythropoietin ameliorates damage to the placenta and fetal liver induced by exposure to lipopolysaccharidePlacenta · 2010
- Erythropoietin: novel approaches to neuroprotection in human brain diseaseMetabolic Brain Disease · 2004
- Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell deathJournal of Neurochemistry · 2006
- Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson’s diseaseNeuroscience · 2007
- Erythropoietin and GDNF enhance ventral mesencephalic fiber outgrowth and capillary proliferation following neural transplantation in a rodent model of Parkinson's diseaseEuropean Journal of Neuroscience · 2006
- Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson’s diseaseBrain Research · 2006
- Erythropoietin as a novel neuroprotectantRestorative neurology and neuroscience · 2004
Related Papers
- CGRP sensory neurons promote tissue healing via neutrophils and macrophagesNature · 2024 · 2 shared tags
- Invited review: Mechanisms of hypophagia during diseaseJournal of Dairy Science · 2021 · 2 shared tags
- Diabetic complications and prospective immunotherapyFrontiers in Immunology · 2023 · 2 shared tags
- Gut-Brain Inflammation Due to Toxin-Activated Mast Cells and Microglia in Autism Spectrum DisorderPreprints.org · 2025 · 2 shared tags
- The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New PerspectivesAntioxidants · 2023 · 2 shared tags
- Herbal Therapeutics for CIRS Biomarkers in Autism Spectrum Disorders: A Mechanistic and Molecular Approach for Neuroimmune Pathology in PediatricsMedical Research Archives · 2026 · 2 shared tags