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The role of complement in danger sensing and transmission

Kohl J2006Immunologic ResearchReview
10.1385/ir:34:2:157PubMed
Immune/InnateNeurological

Abstract

The complement (C) system plays important roles in host defence but activation at inappropriate sites or to an excessive degree can cause host tissue damage. C has been implicated as a factor in the causation or propagation oftissue injury in numer- ous diseases. The brain is an immunologically isolated sitc, sheltered from circulating cells and proteins of the immune sys- tem; nevertheless, there is a growing body of evidence implicat- ing C in numerous brain discascs. In this brief articlc we rcvicw the evidence suggesting a role for C in diseases of the central and peripheral nervous system and discuss the possible sources of C at these sites. Some brain cells synthesise C and also express specific receptors; some are exquisitely sensitive to the lytic effects of C. The evidence suggests that C syr,thesis and activation in the brain are important in immune defence at this site bclt may also play a role in brain disease. .................

Key Biomarkers

C3aComplement receptorsComplement system activation

Symptom Clusters

Brain diseaseCerebral traumaDemyelinationNeurodegeneration

Cited By (4)

  • A dual role for complement in allergic asthmaCurrent Opinion in Pharmacology · 2007
  • Complement activation pathways: a bridge between innate and adaptive immune responses in asthmaProceedings of the American Thoracic Society · 2007
  • Hypothesis: combined inhibition of complement and CD14 as treatment regimen to attenuate the inflammatory responseAdvances in experimental medicine and biology · 2008
  • Complement regulates inhalation tolerance at the dendritic cell/T cell interfaceMolecular Immunology · 2007

References (18)

  • Anaphylatoxins and infectious and non-infectious inflammatory diseasesMolecular Immunology · 2001
  • The dark side of C5a in sepsisNature reviews. Immunology · 2004
  • Signaling the brain in systemic inflammation: the role of complement

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