A dual role for complement in allergic asthma
Abstract
The complement (C) system plays important roles in host defence but activation at inappropriate sites or to an excessive degree can cause host tissue damage. C has been implicated as a factor in the causation or propagation oftissue injury in numer- ous diseases. The brain is an immunologically isolated sitc, sheltered from circulating cells and proteins of the immune sys- tem; nevertheless, there is a growing body of evidence implicat- ing C in numerous brain discascs. In this brief articlc we rcvicw the evidence suggesting a role for C in diseases of the central and peripheral nervous system and discuss the possible sources of C at these sites. Some brain cells synthesise C and also express specific receptors; some are exquisitely sensitive to the lytic effects of C. The evidence suggests that C syr,thesis and activation in the brain are important in immune defence at this site bclt may also play a role in brain disease. .................
Key Biomarkers
Symptom Clusters
References (13)
- The role of complement in danger sensing and transmissionImmunologic Research · 2006
- Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and AsthmaThe Journal of Immunology · 2001
- Pharmacological Targeting of Anaphylatoxin Receptors during the Effector Phase of Allergic Asthma Suppresses Airway Hyperresponsiveness and Airway InflammationThe Journal of Immunology · 2005
- Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophilsThe Journal of Immunology · 2000
- A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthmaJournal of Clinical Investigation · 2006
- Inhibition of complement activation decreases airway inflammation and hyperresponsivenessAmerican Journal of Respiratory and Critical Care Medicine · 2003
- Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma
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