The complement system in regulation of adaptive immunity
Abstract
The serum complement system, which represents a chief component of innate immunity, not only participates in inflammation but also acts to enhance the adaptive immune response. Specific activation of complement via innate recognition proteins or secreted antibody releases cleavage products that interact with a wide range of cell surface receptors found on myeloid, lymphoid and stromal cells. This intricate interaction among complement activation products and cell surface receptors provides a basis for the regulation of both B and T cell responses. This review highlights fundamental events, explaining how complement links innate and adaptive immunity as well as describing more recent studies on how this large family of proteins functions locally in peripheral lymph nodes to enhance B and T cell responses.
Cited By (12)
- The role of complement in danger sensing and transmissionImmunologic Research · 2006
- Complement receptors CD21 and CD35 in humoral immunityImmunological Reviews · 2007
- Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathwayImmunobiology · 2007
- Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturationBlood · 2006
- Complement activation pathways: a bridge between innate and adaptive immune responses in asthmaProceedings of the American Thoracic Society · 2007
- Localization and Characterization of the Mannose-Binding Lectin (MBL)-Associated-Serine Protease-2 Binding Site in Rat Ficolin-A: Equivalent Binding Sites within the Collagenous Domains of MBLs and FicolinsThe Journal of Immunology · 2007
- Regulation of B lymphocyte activation by complement C3 and the B cell co-receptor complex
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