Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6
O. Selberg, Hartmut Hecker, Michael A. Martin +3 more2000Critical Care MedicineJournal Article
CardiovascularImmune/Innate
Abstract
Our data show that the determination of PCT, IL-6, and C3a is more reliable to differentiate between septic and SIRS patients than the variables CRP and elastase, routinely used at the intensive care unit. The determination of PCT and C3a plasma concentrations appears to be helpful for an early assessment of septic and SIRS patients in intensive care.
Key Biomarkers
C-reactive proteinComplement 3aElastaseInterleukin-6Procalcitonin
Symptom Clusters
SepsisSystemic Inflammatory Response Syndrome
Cited By (4)
- Anaphylatoxins and infectious and non-infectious inflammatory diseasesMolecular Immunology · 2001
- The role of complement in danger sensing and transmissionImmunologic Research · 2006
- Circulating complement (C3 and C4) for differentiation of SIRS from sepsisAdvances in Therapy · 2006
- Self, non-self, and danger: a complementary viewAdvances in experimental medicine and biology · 2007
References (3)
- Circulating complement proteins in patients with sepsis or systemic inflammatory response syndromeClinical and Diagnostic Laboratory Immunology · 1996
- Anaphylatoxin generation in multisystem organ failureThe Journal of Trauma: Injury, Infection, and Critical Care · 1984
- Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis
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