Potential clinical applications of vasoactive intestinal peptide: a selected update
Abstract
Neuropeptides are expressed in neurons innervating endocrine cells or in endocrine cells and cancer cells, and are released on site to act as hormones and growth factors. Vasoactive intestinal peptide (VIP) was first discovered in the early 1970s and has since become the area of research for many laboratories. VIP has a neuroendocrine role as it is intimately involved with the synthesis, secretion and action of other neuroendocrine hormones as well as cytokines and chemokines. Major outcomes of VIP downregulation encompass developmental and behavioral dysfunctions, including impaired diurnal rhythms. Overexpression of VIP has been associated with diarrhea and cancer, and overexpression of VIP receptors is associated with cancerous growth. This short review outlines some of the recent progress made in VIP research.
Cited By (4)
- VIP, From Gene to Behavior and Back: Summarizing my 25 Years of ResearchJournal of Molecular Neuroscience · 2008
- Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistryJournal of Molecular Neuroscience · 2007
- Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetesFrontiers in Endocrinology · 2022
- Human VIP-α: an emerging biologic response modifier to treat primary pulmonary hypertensionExpert Review of Cardiovascular Therapy · 2005
References (3)
- Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease1This manuscript is based on a poster presented at the Brain Research Interactive Symposium on “Neuropeptides at the Millennium”, Miami, October 1999.1Brain Research · 2000
- Anti-inflammatory properties of the type 1 and type 2 vasoactive intestinal peptide receptors: role in lethal endotoxic shock
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