VPAC receptors for VIP and PACAP
Abstract
VIP and PACAP are two prominent neuropeptides that share two common G protein-coupled receptors, VPAC1 and VPAC2, while PACAP has an additional specific receptor, PAC1. This article reviews the present knowledge regarding various aspects of VPAC receptors including: 1) receptor specificity toward natural VIP-related peptides and pharmacology of synthetic agonists or antagonists; 2) genomic organization and chromosomal localization; 3) signaling and established or putative interactions with G proteins or accessory proteins such as RAMPs or PDZ-containing proteins; 4) molecular basis of ligand-receptor interaction as determined by site-directed mutagenesis, construction of receptor chimeras, and structural modeling; 5) constitutively active receptor mutants; 6) short-term (desensitization, internalization, phosphorylation) and long-term (transcription) regulations and transgenic models; 7) receptor polymorphisms.
Cited By (7)
- Noncompensation in peptide/receptor gene expression and distinct behavioral phenotypes in VIP- and PACAP-deficient miceJournal of Neurochemistry · 2006
- Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetesFrontiers in Endocrinology · 2022
- PACAP, VIP and their receptors in the metazoa: insights about the origin and evolution of the ligand-receptor pairPeptides · 2007
- The many faces of VIP in neuroimmunology: a cytokine rather a neuropeptideThe FASEB Journal · 2004
- Role of VIP and PACAP in islet functionPeptides · 2007
- Potential clinical applications of vasoactive intestinal peptide: a selected updateBest Practice & Research Clinical Endocrinology & Metabolism · 2004
- VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 And VPAC2 receptors
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