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VIP, From Gene to Behavior and Back: Summarizing my 25 Years of Research

Gozes I2008Journal of Molecular NeuroscienceNarrative Review
10.1007/s12031-008-9105-3PubMed
Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryNeurological

Abstract

Vasoactive intestinal peptide (VIP) is an interest- ing example of a 28-amino acid neuropeptide that is abundantly expressed in discrete brain regions/neurons and hence may contribute to brain function. This short review summarizes my own point of view and encompasses 25 years of work and over 100 publications targeting the understanding of VIP production and biological activity. The review starts with our original cloning of the VIP gene, it then continues to discoveries of regulation of VIP synthesis and the establishment of the first VIP transgenic mice. The review ends with the identification of novel VIP analogs that helped decipher VIP’s important role during development, in regulation of the biological clock(s) and diurnal rhythms, sexual activity, learning and memory as well as social behavior, and cancer. This review cites only articles that I have coauthored and gives my own perspective of this exciting ever-growing field.

Key Biomarkers

PHM27/PHI27VIP (Vasoactive Intestinal Peptide)VIP mRNA

Symptom Clusters

Circadian Rhythm DisordersLearning and Memory ImpairmentSexual DysfunctionSocial Behavioral Abnormalities

Cited By (1)

  • VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studiesCurrent Opinion in Endocrinology Diabetes and Obesity · 2011

References (8)

  • Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistryJournal of Molecular Neuroscience · 2007
  • Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease1This manuscript is based on a poster presented at the Brain Research Interactive Symposium on “Neuropeptides at the Millennium”, Miami, October 1999.1Brain Research · 2000
  • VIP provides cellular protection through a specific splice variant of the PACAP receptor: a new neuroprotection targetPeptides · 2006
  • Identity of Neurotrophic Molecules Released from Astroglia by Vasoactive Intestinal PeptideaAnnals of the New York Academy of Sciences · 1997
  • Vasoactive Intestinal Peptide (VIP) Regulates Activity-Dependent Neuroprotective Protein (ADNP) Expression In Vivo

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