PHARMACOKINETICS OF HALOGENATED HYDROCARBONS
Abstract
Pharmacokinetic modeling is being applied to chemicals posing health hazards because of their presence as contaminants in our environment. This paper presents a rationale for constructing mathematical models based on anatomic and physiological principles. Pharmacokinetic investigations incorporating such models are illustrated for two halogenated hydrocarbons that exhibit different patterns of disposition in the rat: 2,2',4,4',5,5'-hexachlorobiphenyl and Kepone. The models permit interspecies comparison and prediction of normal pharmacokinetic behavior and alterations induced by intervention measures. As an example a theoretical limit is predicted in the case of a treatment for Kepone poisoning involving oral administration of adsorbents.
Part of Endotoxins research, Mold & water-damaged buildings research, Mycotoxins research, CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady
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Cited By (4)
- Chronic biotoxin-associated illness: Multiple-system symptoms, a vision deficit, and effective treatmentNeurotoxicology and Teratology · 2005
- Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
- A time-series study of sick building syndrome: chronic, biotoxin-associated illness from exposure to water-damaged buildingsNeurotoxicology and Teratology · 2005
- Possible estuary-associated syndrome: symptoms, vision, and treatment.Environmental Health Perspectives · 2001
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