Cholestyramine: Use as a New Therapeutic Approach for Chlordecone (Kepone) Poisoning

Boylan JJ; Egle JL; Guzelian PS

doi:10.1126/science.74852

Cholestyramine: Use as a New Therapeutic Approach for Chlordecone (Kepone) Poisoning

Boylan JJ, Egle JL, Guzelian PS1978ScienceJournal Article

10.1126/science.74852 PubMed

Gastrointestinal

Other Biotoxins

Abstract

In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

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