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α-Melanocyte-stimulating Hormone in Normal Human Physiology and Disease States

Catania A, Airaghi L, Colombo G +1 more2000Trends in Endocrinology and MetabolismReview
10.1016/s1043-2760(00)00296-4PubMed
Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryImmune/Innate

Abstract

Over the past two decades, research in animal models has indicated that alpha-melanocyte-stimulating hormone (alpha-MSH) has potent anti-inflammatory properties. Furthermore, recent data show that the peptide has antimicrobial effects and probably contributes to innate immunity. alpha-MSH, which is produced by many extrapituitary human cells, should no longer be considered solely a pituitary hormone; rather, it should be viewed as a ubiquitous modulatory peptide.

Key Biomarkers

Alpha-melanocyte-stimulating hormone (alpha-MSH)

Cited By (9)

  • The nervous system and innate immunity: the neuropeptide connectionNature Immunology · 2005
  • Targeting melanocortin receptors as a novel strategy to control inflammationPharmacological Reviews · 2004
  • Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humorInternational Immunopharmacology · 2004
  • PRODUCTION AND EFFECTS OF α-MELANOCYTE-STIMULATING HORMONE DURING ACUTE LUNG INJURYShock · 2007
  • Alpha-Melanocyte-Stimulating Hormone-Mediated Appetite Regulation in the Central Nervous SystemNeuroendocrinology · 2023
  • Electroporative α-MSH gene transfer attenuates thioacetamide-induced murine hepatic fibrosis by MMP and TIMP modulationGene Therapy · 2006
  • Central neurotranspeptide, alpha-melanocyte-stimulating hormone (alpha-MSH) is upregulated in patients with congestive heart failure

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    • References (12)

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