Recurrent erythema migrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection
Liegner KB, Shapiro JR, Ramsay D +3 more1993Journal of the American Academy of DermatologyJournal Article
DermatologicalImmune/InnateNeurological
Lyme & Co-Infections
Abstract
Erythema migrans recurred in a patient 6 months after a course of treatment with minocycline for Lyme disease. Polymerase chain reaction on heparinized peripheral blood at that time demonstrated the presence of Borrelia burgdorferi-specific DNA. The patient was seronegative by Lyme enzyme-linked immunosorbent assay but showed suspicious bands on Western blot. Findings of a Warthin-Starry stain of a skin biopsy specimen of the eruption revealed a Borrelia-compatible structure. Reinfection was not believed to have occurred. Further treatment with minocycline led to resolution of the erythema migrans.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Borrelia burgdorferiErythema migransIgG antibodiesIgM antibodies
Symptom Clusters
DepressionLyme encephalopathyMemory impairmentPersistent infection despite antibiotic treatmentRecurrent erythema migrans
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