Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients

Abstract

Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients Lilija ~ovalcl~uka'* * Corresponding author Email: Lilija.Kovalcuka@rsu.Iv Jelena ~ g l i t e ' Email: Elena.Eglite@rsu.lv Mara zalite2" Email: Mara.zalite@rsu.lv Ludmila ~ i k s n a ~ . ~ Email: Ludmila.viksna@rsu.Iv Angelika ~rumina' Etnail: angelika@covalent.lv I Riga StradinS University, Clinical T~nmunology and Im~nunogenetic laboratory, Kronvalda str.9, Riga, Latvia 2 Riga StradiyS University, Infectology and Dertnatology department, L,inezera 3, Riga, Latvia Riga StradinS University Infectology and Dernlatology Department, Infectology Center of Latvia, Linezera 3, Riga, Latvia 1 Background Many autoimmune diseases are associated with variants of HLA genes such as those encodillg the MHC complex. This correlation is not absolute, but tnay help in ~~nderstanding of the molecular mechanism of disease. The purpose of this study was to deterlnine HLA- DR,-DQ alleles in Latvian patients with Lyme borreliosis and colltrol (healthy) persons. Case patients and cotitrol subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of Borreliu burgdorferi infection. The study included 25 patients with clinical stage - erythema niigrutzs and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.

Key Biomarkers

Symptom Clusters