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Microbiological and serological diagnosis of Lyme Borreliosis

Wilske B, Fingerle V, Schulte-Spechtel U2007FEMS Immunology & Medical MicrobiologyReview
10.1111/j.1574-695x.2006.00139.xPubMedFree full text
CardiovascularMusculoskeletalNeurological
Lyme & Co-Infections

Abstract

. 56. Drouin EE, Seward RJ, Yao C, Costello CE, Steere AC. A novel Human Autoantigen Endothelial Cell Growth Factor Induces Linked T and B Cell Responses in Patients with Antibiotic-Refractory Lyme Arthritis. ICAAC 2010. Abstract. 57. Gross DM, Forsthuber T, Tary-Lehmann M, et al. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science. 1998;281:703-6. 58. Jones KL, McHugh GA, Glickstein LJ, Steere AC. Analysis of Borrelia burgdorferi genotypes in patients with Lyme arthritis: High frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis. Arthritis Rheum. 2009;60:2174-82. 59. Codolo G, Amedei A, Steere AC, et al. Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis. Arthritis Rheum. 2008;58:3609-17. 60. Shen S, Shin JJ, Strle K, et al. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis Rheum. 2010;62:2127-37. 61. Gasser R, Dusleag J, Reisinger E, et al. Reversal by ceftriaxone of dilated cardiomyopathy Borrelia burgdorferi infection. Lancet. 1992;339:1174-5. 62. Marques A. Chronic Lyme disease: a review. Infect Dis Clin North Am. 2008;22:341-60, vii-viii. 63. Feder HM Jr, Johnson BJ, O’Connell S, et al. A critical appraisal of “chronic Lyme disease”. N Engl J Med. 2007;357:1422-30. 64. Luo N, Johnson JA, Shaw JW, Feeny D, Coons SJ. Self-reported health status of the general adult U.S. population as assessed by the EQ-5D and Health Utilities Index. Med Care. 2005;43:1078-86. 65. Gutierrez J, Guerrero M, Nunez F, Soto MJ, Piedrola G, Maroto MC. Antibodies to Borrelia burgdorferi in European populations. J Clin Lab Anal. 2000;14:20-6. 66. Carlsson SA, Granlund H, Nyman D, Wahlberg P. IgG seroprevalence of Lyme borreliosis in the population of the Aland Islands in Finland. Scand J Infect Dis. 1998;30:501-3. 67. Fallon BA, Keilp JG, Corbera KM, et al. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology. 2008;70:992-1003. 68. Klempner MS, Hu LT, Evans J, et al. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med. 2001;345:85-92. 69. Krupp LB, Hyman LG, Grimson R, et al. Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology. 2003;60:1923-30. 70. Kaplan RF, Trevino RP, Johnson GM, et al. Cognitive function in post-treatment Lyme disease: do additional antibiotics help? Neurology. 2003;60:1916-22. 71. Moody KD, Adams RL, Barthold SW. Effectiveness of antimicrobial treatment against Borrelia burgdorferi infection in mice. Antimicrob Agents Chemother. 1994;38:1567-72. 72. Straubinger RK, Summers BA, Chang YF, Appel MJ. Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment. J Clin Microbiol. 1997;35:111-6. 73. Wormser GP, Schwartz I. Antibiotic treatment of animals infect

Key Biomarkers

IgG antibodies to Borrelia burgdorferiPCR detection of B. burgdorferiSerological markers

Symptom Clusters

CardiomyopathyEarly disseminated manifestationsLate disseminated manifestationsLyme arthritis

Cited By (3)

  • Chronic Lyme disease: a reviewInfectious Disease Clinics of North America · 2008
  • Inflammation and central nervous system Lyme diseaseNeurobiology of Disease · 2010
  • Acylated cholesteryl galactosides are specific antigens of Borrelia causing Lyme disease and frequently induce antibodies in late stages of diseaseJournal of Biological Chemistry · 2009

References (9)

  • Recombinant immunoblot in the serodiagnosis of Lyme borreliosisMedical Microbiology and Immunology · 1993
  • Sensitive and Specific Serodiagnosis of Lyme Disease by Enzyme-Linked Immunosorbent Assay with a Peptide Based on an Immunodominant Conserved Region ofBorrelia burgdorferiVlsEJournal of Clinical Microbiology · 1999
  • Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosisClinical Infectious Diseases · 1993

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