Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Abstract
Regulatory T (T(Reg)) cells constitute a unique T-cell lineage that has a crucial role in immunological tolerance. Several years ago, forkhead box P3 (FOXP3) was identified as the transcription factor that was responsible for determining the development and function of these cells. However, the underlying mechanisms that are involved in the regulation of the FOXP3 gene remain unclear and therefore preclude accurate identification and manipulation of T(Reg) cells. In this Progress article, we summarize recent advances in understanding how FOXP3 expression is controlled and highlight evidence suggesting that epigenetic regulation of the FOXP3 locus contributes to its role as a lineage-specification factor.
Key Biomarkers
Cited By (9)
- Inflammation-driven reprogramming of CD4+Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivoPLoS ONE · 2012
- Function and Role of Regulatory T Cells in Rheumatoid ArthritisFrontiers in Immunology · 2021
- Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cellsImmunity · 2012
- Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cellsVaccine · 2011
- FOXP3 and RORγt: Transcriptional regulation of Treg and Th17International Immunopharmacology · 2011
- The Foxp3 interactome: a network perspective of Treg cellsNature Immunology · 2012
- Developmental plasticity of Foxp3+ regulatory T cells
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