FOXP3 and RORγt: Transcriptional regulation of Treg and Th17
Abstract
FOXP3(+)CD4(+)CD25(+) Regulatory T (Treg) cells and IL-17 producing helper T cells (Th17) are critical subsets of T cells which play essential roles in immune homeostasis. The Forkhead family transcription factor FOXP3 is predominantly expressed in Treg cells, where the FOXP3 ensemble is essential for Treg cell development and function. As FOXP3 is to Treg cells, the orphan retinoic acid nuclear receptor (ROR) family transcription factor RORγt is essential for Th17 development and function. In this review, we summarize recent progress of our understanding towards the molecular mechanisms underlying the differentiation and function of FOXP3(+) Treg cells and RORγt expressing Th17 cells. These may provide new insights into therapeutic intervention and targeting of human immune-deficient diseases.
Key Biomarkers
References (6)
- Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3The Journal of Experimental Medicine · 2003
- Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?Nature reviews. Immunology · 2009
- Epigenetic inheritance of DNA methylation limits activation-induced expression of FoxP3 in conventional human CD25-CD4+ T cellsInternational Immunology · 2008
- DNA methylation controls Foxp3 gene expressionEuropean Journal of Immunology · 2008
- Fang D.Foxp3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1Blood · 2008
- IL-17 and Th17 cellsAnnual Review of Immunology · 2009
Related Papers
- Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177Frontiers in Immunology · 2022 · 1 shared tag
- Effects of Omega-3 Polyunsaturated Fatty Acids on the Formation of Adipokines, Cytokines, and Oxylipins in Retroperitoneal Adipose Tissue of MiceInternational Journal of Molecular Sciences · 2024 · 1 shared tag
- Fungal immunity and pathogenesis in mammals versus the invertebrate model organismGalleria mellonellaPathogens and Disease · 2021 · 1 shared tag
- TLR signaling pathway and the effects of main immune cells and epigenetics factors on the diagnosis and treatment of infertility and sterilityHeliyon · 2024 · 1 shared tag
- CGRP sensory neurons promote tissue healing via neutrophils and macrophagesNature · 2024 · 1 shared tag
- Invited review: Mechanisms of hypophagia during diseaseJournal of Dairy Science · 2021 · 1 shared tag