Isolation and Identification of Aspergillus fumigatus Mycotoxins on Growth Medium and Some Building Materials
Nieminen SM, Karki R, Auriola S +5 more2002Applied and Environmental MicrobiologyJournal Article
CardiovascularEndocrine (ADH/ACTH/MSH)GastrointestinalHypothalamic-PituitaryImmune/InnateMusculoskeletalNeurologicalOcularRespiratory/Sinus
Bacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsVolatile Organic Compounds (VOCs)Water-Damaged Buildings (WDB)
Abstract
ABSTRACT Genotoxic and cytotoxic compounds were isolated and purified from the culture medium of an indoor air mold, Aspergillus fumigatus . One of these compounds was identified as gliotoxin, a known fungal secondary metabolite. Growth of A. fumigatus and gliotoxin production on some building materials were also studied. Strong growth of the mold and the presence of gliotoxin were detected on spruce wood, gypsum board, and chipboard under saturation conditions.
Key Biomarkers
Alpha Melanocyte Stimulating Hormone (MSH)Immunoglobulin E (IgE)LeptinMatrix Metalloproteinase 9 (MMP9)Vascular Endothelial Growth Factor (VEGF)Visual Contrast Sensitivity (VCS)
Symptom Clusters
Appetite swingsConfusionCoughDifficulty with concentrationExcessive thirstFatigueFrequent urinationHeadacheJoint painLight sensitivityMemory lossMood swingsMuscle achesNight sweatsShortness of breathSinus congestionTingling in extremitiesWord finding difficulty
Cited By (6)
- Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
- Neural autoantibodies and neurophysiologic abnormalities in patients exposed to molds in water-damaged buildingsArchives of Environmental Health An International Journal · 2003
- Can we use indoor fungi as bioindicators of indoor air quality? Historical perspectives and open questionsThe Science of The Total Environment · 2010
- Mycotoxin production by indoor moldsFungal Genetics and Biology · 2003
- Silver-109/Silver/Gold Nanoparticle-Enhanced Target Surface-Assisted Laser Desorption/Ionisation Mass Spectrometry—The New Methods for an Assessment of Mycotoxin Concentration on Building MaterialsToxins · 2021
- Filamentous microorganisms and their fragments in indoor air- a reviewPubMed · 2004
Related Papers
- Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarumEnvironmental Health Perspectives · 2004 · 14 shared tags
- Comparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strainsToxicological Sciences · 2004 · 14 shared tags
- Localization of Satratoxin-G in Stachybotrys chartarum Spores and Spore-Impacted Mouse Lung Using ImmunocytochemistryToxicologic Pathology · 2004 · 14 shared tags
- Correction to “Maitotoxin induces biphasic interleukin-1β secretion and membrane blebbing in murine macrophages”Mol Pharmacol · 2004 · 14 shared tags
- HUMAN VISUAL FUNCTION IN THE NORTH CAROLINA CLINICAL STUDYON POSSIBLE ESTUARY-ASSOCIATED SYNDROMEJournal of Toxicology and Environmental Health · 2001 · 14 shared tags
- Effectiveness of cholestyramine in the detoxification of zearalenone as determined in miceBulletin of Environmental Contamination and Toxicology · 1995 ·