Toxic-Metabolite-Producing Bacteria and Fungus in an Indoor Environment
Abstract
ABSTRACT Toxic-metabolite-emitting microbes were isolated from the indoor environment of a building where the occupant was suffering serious building-related ill-health symptoms. Toxic substances soluble in methanol and inhibitory to spermatozoa at <10 μg (dry weight) ml −1 were found from six bacterial isolates and one fungus. The substances from isolates of Bacillus simplex and from isolates belonging to the actinobacterial genera Streptomyces and Nocardiopsis were mitochondriotoxic. These substances dissipated the mitochondrial membrane potential (Δψ) of boar spermatozoa. The substances from the Streptomyces isolates also swelled the mitochondria. The substances from isolates of Trichoderma harzianum Rifai and Bacillus pumilus damaged the cell membrane barrier function of sperm cells.
Key Biomarkers
Symptom Clusters
Cited By (11)
- The biocontaminants and complexity of damp indoor spaces: more than what meets the eyesToxicology and Industrial Health · 2009
- Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
- Neural autoantibodies and neurophysiologic abnormalities in patients exposed to molds in water-damaged buildingsArchives of Environmental Health An International Journal · 2003
- Biological Effects of Trichoderma harzianum Peptaibols on Mammalian CellsApplied and Environmental Microbiology · 2004
- Mycotoxin production by indoor moldsFungal Genetics and Biology · 2003
- Cognitive function of 6-year old children exposed to mold-contaminated homes in early postnatal period. Prospective birth cohort study in PolandPhysiology & Behavior · 2011
- Overview of fungal isolates on heritage collections of photographic materials and their biological potency
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