Toxic-Metabolite-Producing Bacteria and Fungus in an Indoor Environment
Abstract
Toxic-metabolite-emitting microbes were isolated from the indoor environment of a building where the occupant was suffering serious building-related ill-health symptoms. Toxic substances soluble in methanol and inhibitory to spermatozoa at <10 microg (dry weight) ml(-1) were found from six bacterial isolates and one fungus. The substances from isolates of Bacillus simplex and from isolates belonging to the actinobacterial genera Streptomyces and Nocardiopsis were mitochondriotoxic. These substances dissipated the mitochondrial membrane potential (Deltapsi) of boar spermatozoa. The substances from the Streptomyces isolates also swelled the mitochondria. The substances from isolates of Trichoderma harzianum Rifai and Bacillus pumilus damaged the cell membrane barrier function of sperm cells.
Part of Endotoxins research, Mold & water-damaged buildings research, Mycotoxins research, CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Symptom Clusters
Cited By (11)
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- Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
- Neural autoantibodies and neurophysiologic abnormalities in patients exposed to molds in water-damaged buildingsArchives of Environmental Health An International Journal · 2003
- Biological Effects of Trichoderma harzianum Peptaibols on Mammalian CellsApplied and Environmental Microbiology · 2004
- Mycotoxin production by indoor moldsFungal Genetics and Biology · 2003
- Cognitive function of 6-year old children exposed to mold-contaminated homes in early postnatal period. Prospective birth cohort study in PolandPhysiology & Behavior · 2011
- Overview of fungal isolates on heritage collections of photographic materials and their biological potencyJournal of Cultural Heritage · 2021
- Occupational Microbiological Biohazards – Exposure, Detection, and DiseasePatty's Industrial Hygiene · 2021
- The Toxicity of Wiped Dust and Airborne Microbes in Individual Classrooms Increase the Risk of Teachers’ Work-Related Symptoms: A Cross-Sectional StudyPathogens · 2021
- Diversity of streptomycetes in water-damaged building materials based on 16S rDNA sequencesLetters in Applied Microbiology · 2002
- Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune ProcessesClinical Therapeutics · 2018
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