Inflammatory brain changes in Lyme borreliosis
Abstract
Brain (1996), 119, 2 143-2 154 Inflammatory brain changes in Lyme borreliosis A report on three patients and review of literature J. O k ~ i , ' . ~ . ~ H. ~ a l i m o , ~ R. J. Martti~a,~ P. S~nninen,~ M. Marjamaki,' J. Nikoskelainen' and M. K. Viljanet~~.~ Depc7rtmerrrs of Ilnrernal Medicrne. 2Parhology 3~eurology and 'Radiology, Turk11 Universiy Central Hospiral, jDeparrmenr af Medical Microbiology Turku Universin "uriorlul Public Heallh Insrirure, Depamnenl in Turku and '~urkrr Immunology Cenrre. Turku. Finland Summary Despite u rapid rncreu.re in rl~e number o/ parienrs with Lyme r~e~trohorreliosis (LAB), irs neuropalhological aspects rrre poorl,~ rmdersrood. The objective of rllis srudv was e~~uluarion of neuropathological, microbiological, and rrwgtleric resotwnce imaging (MRI) findings in three purienrs rr*irh /Ire Borreliu hurgdorferi infecriorr and neurological di.ret~.refrom \rjhom brain rissue specimens rcrere availrible. Perivtrsculur or vasculiric Iympl~oc~/icitlfimmarion ~vas detected it1 ull sljrcirnens. Lcrrge ureas of demyelinarion in peri~enrricular lvlrite murrer were detected hisrologically artd by MRI irt one patient. The diseuse had a fala1 ourconle in /his pc~tienr. Bruit1 MRI sugge.r/ed malignancies in ~ M J O Correspondence 10: J. Oksi. Turku University, Deparrnlen! of Medical Microbiology Kiinamyllvnkaru 13, FIN-20520 Trrrku. Finland purients before hisroparhological srudies were carricd our. One of rl~ese tn)opa/ien/s was a child rvirh sudden I~emiparesis. Anorher was a 40-year-old marl presenling wirh epilepric seizures and MRI-derecred mulrifocal lesions, which disappeared ujier repealed courses of arltibiorics. We conclude rhar cerebral lympl~ocy/ic vascu1iri.r and rnultifncol encepl~aliris m y be ussocicrred wirh B. burgdorferi in/ec!ion. The presence of B. burgdorferi DNA in tissue samples from areas rvirh inflammarory cl~anges indicates rhar direcr itlvusion ofB. burgdotferi my be /he parhogeneric mechanism for focul encephaliris in
Key Biomarkers
Symptom Clusters
References (6)
- Demyelinating encephalopathy in Lyme diseaseNeurology · 1985
- Antibodies against whole sonicated Borrelia burgdorferi spirochetes, 41-kilodalton flagellin, and P39 protein in patients with PCR- or culture-proven late Lyme borreliosisJournal of Clinical Microbiology · 1995
- Sequestration of antibody to Borrelia burgdorferi in immune complexes in seronegative Lyme diseaseThe Lancet · 1990
- Chronic progressive neurological involvement in Borrelia burgdorferi infectionJournal of Neurology · 1987
- Clinical Pathologic Correlations of Lyme DiseaseClinical Infectious Diseases · 1988
- Concurrent neocortical borreliosis and Alzheimer’s disease
Related Papers
- Herbal Therapeutics for CIRS Biomarkers in Autism Spectrum Disorders: A Mechanistic and Molecular Approach for Neuroimmune Pathology in PediatricsMedical Research Archives · 2025 · 3 shared tags
- Exploring Structured Camel Milk Therapy Alongside an Individualised Botanical Support Protocol to Facilitate Immune Modulation in a Child Diagnosed with PANS/PANDAS Co-Morbid with Lyme Disease and AutismJournal of Camel Practice and Research · 2025 · 3 shared tags
- Neuroplasticity Intervention, Amygdala and Insula Retraining (AIR), Significantly Improves Overall Health and Functioning Across Various Chronic Conditions.PubMed · 2023 · 3 shared tags
- Introduction to Chronic Inflammatory Response Syndrome (CIRS)2023 · 3 shared tags
- TUBB1, TUBA4A and MAPK as Indicators of Die-Back Degenerative Central Nervous System Disease in Patients Sickened by Specific Exposure to the Interior Environment of Water- Damaged BuildingsMedical Research Archives · 2023 · 3 shared tags
- Autism Spectrum Disorders and Lyme Disease: Exploring Shared Neuro-Inflammatory and Immune Pathways