← Explorer/Network

Clinical observations on 3,009 cases of ciguatera (fish poisoning) in the South Pacific

R. Bagnis, T. Kuberski, S. Laugier1979American Journal of Tropical Medicine and HygieneJournal Article
10.4269/ajtmh.1979.28.1067PubMed
GastrointestinalNeurological
Dinoflagellates/Ciguatera

Abstract

Clinical observations on ciguatera were collected between 1964 and 1977 on 3,009 patients from several South Pacific island groups. Patients generally presented with neurologic symptoms such as parasthesia, vertigo, and ataxia, in addition to gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, and vomiting. Patients with this illness usually became symptomatic less than 24 hours after ingestion of the fish and most patients (76.8%) developed symptoms in less than 12 hours. Significant differences in certain symptoms were noted between Melanesian and Polynesian ethnic groups, suggesting a susceptibility difference, or a difference in the nature of the toxin found in different areas of the Pacific. Being poisoned multiple times appeared to result in a clinically more severe illness than disease observed in patients experiencing ciguatera for the first time.

Symptom Clusters

Abdominal painAtaxiaDiarrheaNauseaParesthesiaVertigoVomiting

Cited By (37)

  • Pacific ciguatoxin 1B-induced modulation of inflammatory mediators in a murine macrophage cell lineToxicon · 2010
  • Ciguatera fish poisoningNeurology · 2002
  • First Confirmed Occurrence of Ciguatera Poisoning in the UK from Imported Pinjalo Snapper (Pinjalo pinjalo)Marine Drugs · 2025
  • An Update on Ciguatoxins and CTX-like Toxicity in Fish from Different Trophic Levels of the Selvagens Islands (NE Atlantic, Madeira, Portugal)Toxins · 2021
  • Ciguatera Fish Poisoning: Treatment, Prevention and ManagementMarine Drugs · 2008
  • Critical Review and Conceptual and Quantitative Models for the Transfer and Depuration of Ciguatoxins in FishesToxins · 2021
  • Neurobehavioral effects of harmful algal bloom (HAB) toxins: a critical reviewJournal of the International Neuropsychological Society · 2005

Related Papers

  • Clinical Characteristics of Ciguatera Fish Poisoning in Martinique, French West Indies – A Case SeriesPreprints.org · 2022 · 3 shared tags
  • Chronic Ciguatera Poisoning: A Case ReportWilderness and Environmental Medicine · 2023 · 3 shared tags
  • TUBB1, TUBA4A and MAPK as Indicators of Die-Back Degenerative Central Nervous System Disease in Patients Sickened by Specific Exposure to the Interior Environment of Water- Damaged BuildingsMedical Research Archives · 2023 · 3 shared tags
  • Local and Traditional Ecological Knowledge of Fish Poisoning in FijiToxins · 2023 · 3 shared tags
  • A Case of Ciguatera Fish Poisoning in South GeorgiaCureus · 2022 · 3 shared tags
  • Effects of synthetic ciguatoxin CTX3C and 44-methylgambierone (MTX3) on voltage-gated sodium channels and their in vivo toxicity2021 · 3 shared tags
  • Ciguatera poisoning in French Polynesia: A review of the distribution and toxicity of Gambierdiscus spp., and related impacts on food web components and human healthHarmful Algae · 2023
  • Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory NeuronsMarine Drugs · 2021
  • Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxinBMC Medical Genomics · 2015
  • Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus)Toxicon · 1997
  • Prevalence of chronic symptoms of ciguatera disease in French Polynesian adultsAmerican Journal of Tropical Medicine and Hygiene · 2007
  • In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicityArchives of Toxicology · 2022
  • Temporal trends and epidemiological aspects of ciguatera in French Polynesia: a 10-year analysisTropical Medicine & International Health · 2007
  • Mild ciguatera poisoning: Case reports with neurophysiological evaluationsMuscle & Nerve · 2000
  • Ciguatera poisoningPractical Neurology · 2007
  • Harmful algal bloomsElsevier eBooks · 2023
  • Ciguatera poisoning in VanuatuAmerican Journal of Tropical Medicine and Hygiene · 2003
  • Prevalence, symptoms and chronicity of ciguatera in New Caledonia: results from an adult population survey conducted in Noumea during 2005Toxicon · 2010
  • Clinical features of ciguatera fish poisoning. A study of the disease in the US Virgin IslandsToxicon · 1982
  • Neuropsychological study of ciguatera fish poisoning: a longitudinal case-control studyArchives of Clinical Neuropsychology · 2007
  • A pilot study for the detection of acute ciguatera intoxication in human bloodJournal of Toxicology Clinical Toxicology · 2002
  • Ciguatera fish poisoning in the Caribbean Islands and Western AtlanticReviews of Environmental Contamination and Toxicology · 2001
  • The changing face of ciguateraToxicon · 2001
  • Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fishToxicon · 2007
  • Ciguatera: recent advances but the risk remainsInternational Journal of Food Microbiology · 2000
  • Use of two detection methods to discriminate ciguatoxins from brevetoxins: application to great barracuda from Florida KeysToxicon · 2005
  • Biomonitoring of ciguatoxin exposure in mice using blood collection cardsToxicon · 2005
  • Ciguatera fish poisoning in MiamiJAMA · 1980
  • Study of factors that influence the clinical response to ciguatera fish poisoningToxicon · 1993
  • Foodborne toxins of marine origin: ciguateraReviews of Environmental Contamination and Toxicology · 1991
  • Action of ciguatoxin on human atrial trabeculaeToxicon · 1992
  • The basis of the paradoxical disturbance of temperature perception in ciguatera poisoningJournal of Toxicology Clinical Toxicology · 1993
  • Neurotoxic marine poisoningThe Lancet Neurology · 2005
  • Polymyositis after ciguatera toxin exposureArchives of Neurology · 1991
  • Origin and transfer of toxins involved in ciguateraComparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · 1993
  • Potential benefit of tocainide in the treatment of ciguatera: report of three casesThe American Journal of Medicine · 1988