Mild ciguatera poisoning: Case reports with neurophysiological evaluations
Raffaella Butera, Leon D. Prockop, Michelangelo Buonocore +3 more2000Muscle & NerveJournal Article
GastrointestinalNeurological
Dinoflagellates/Ciguatera
Abstract
Ciguatera poisoning causes mainly gastrointestinal and neurological effects of variable severity. However, symptoms of peripheral neuropathy with paresthesias and paradoxical disturbance of thermal sensation are the hallmark. Electrophysiological studies are often normal, except in severe cases. We report four people who developed mild ciguatera poisoning after barracuda ingestion. Electrophysiological studies documented normocalcemic latent tetany. These findings are consistent with ciguatoxin's mechanism of toxicity, which involves inactivation of voltage-gated Na(+) channels and eventually increases nerve membrane excitability.
Key Biomarkers
Abnormal nerve membrane excitabilityNormocalcemic latent tetanyVoltage-gated Na+ channel inactivation
Symptom Clusters
Gastrointestinal effectsParadoxical thermal sensation disturbanceParesthesiasPeripheral neuropathy
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- Neurologic signs of ciguatera disease: evidence of their persistenceAmerican Journal of Tropical Medicine and Hygiene · 2007
- Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory NeuronsMarine Drugs · 2021
- Ciguatera poisoningPractical Neurology · 2007
- Reversible cerebellar dysfunction associated with ciguatera fish poisoningJournal of Emergency Medicine · 2012
- Neurotoxic marine poisoningThe Lancet Neurology · 2005
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