← Explorer/Network

The changing face of ciguatera

Lewis RJ2001ToxiconReview
10.1016/s0041-0101(00)00161-6PubMed
CardiovascularGastrointestinalNeurological
Dinoflagellates/Ciguatera

Abstract

Ciguatera is a global disease caused by the consumption of certain warm-water fish (ciguateric fish) that have accumulated orally effective levels of sodium channel activator toxins (ciguatoxins) through the marine food chain. Symptoms of ciguatera include a range of gastrointestinal, neurological and cardiovascular disturbances. This review examines progress in our understanding of ciguatera from the work of Banner in the late 1950s to the present. Similarities and differences in ciguatera in the Pacific Ocean, Indian Ocean and Caribbean Sea are highlighted, and future research directions are suggested.

Cited By (20)

  • Defining the neurotoxin derived illness chronic ciguatera using markers of chronic systemic inflammatory disturbances: A case/control studyNeurotoxicology and Teratology · 2010
  • Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective responseBMC Neuroscience · 2010
  • Pacific ciguatoxin 1B-induced modulation of inflammatory mediators in a murine macrophage cell lineToxicon · 2010
  • Ciguatera Fish Poisoning: Treatment, Prevention and ManagementMarine Drugs · 2008
  • Ciguatera Mini Review: 21st Century Environmental Challenges and the Interdisciplinary Research Efforts Rising to Meet ThemInternational Journal of Environmental Research and Public Health · 2021
  • Marine Algal Toxins and Public Health: Insights from Shellfish and Fish, the Main Biological VectorsMarine Drugs · 2024

Related Papers

  • Clinical Characteristics of Ciguatera Fish Poisoning in Martinique, French West Indies – A Case SeriesPreprints.org · 2022 · 4 shared tags
  • A Case of Ciguatera Fish Poisoning in South GeorgiaCureus · 2022 · 4 shared tags
  • Effects of synthetic ciguatoxin CTX3C and 44-methylgambierone (MTX3) on voltage-gated sodium channels and their in vivo toxicity2021 · 4 shared tags
  • Ciguatera Toxin Syndrome from Amberjack Ingestion as a Cause of Chronic Dermatitis with Episodic ErythemaCureus · 2023 · 4 shared tags
  • A cell-based assay for brevetoxins, saxitoxins, and ciguatoxins using a stably expressed c-fos-luciferase reporter geneAnalytical Biochemistry · 1997 · 4 shared tags
  • Ciguatera: recent advances but the risk remainsInternational Journal of Food Microbiology · 2000 · 4 shared tags
Critical Review and Conceptual and Quantitative Models for the Transfer and Depuration of Ciguatoxins in Fishes
Toxins · 2021
  • The Occurrence, Distribution, and Toxicity of High-Risk Ciguatera Fish Species (Grouper and Snapper) in Kiritimati Island and Marakei Island of the Republic of KiribatiToxins · 2022
  • Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxinBMC Medical Genomics · 2015
  • Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory NeuronsMarine Drugs · 2021
  • “Algal-dromes”: a novel conceptual approach to illness in humans exposed to harmful algal bloom toxinsFrontiers in Toxicology · 2026
  • Total synthesis of ciguatoxin CTX3C: a venture into the problems of ciguatera seafood poisoningThe Chemical Record · 2005
  • In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicityArchives of Toxicology · 2022
  • Temporal trends and epidemiological aspects of ciguatera in French Polynesia: a 10-year analysisTropical Medicine & International Health · 2007
  • Ciguatera poisoningPractical Neurology · 2007
  • Ciguatera poisoning in VanuatuAmerican Journal of Tropical Medicine and Hygiene · 2003
  • Neuropsychological study of ciguatera fish poisoning: a longitudinal case-control studyArchives of Clinical Neuropsychology · 2007
  • A pilot study for the detection of acute ciguatera intoxication in human bloodJournal of Toxicology Clinical Toxicology · 2002
  • Production of monoclonal antibodies for sandwich immunoassay detection of ciguatoxin 51-hydroxyCTX3CToxicon · 2006
  • Neurotoxic marine poisoningThe Lancet Neurology · 2005

    • References (6)

    • Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus)Toxicon · 1997
    • Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extractsJournal of AOAC International · 1995
    • Nodal swelling produced by ciguatoxin-induced selective activation of sodium channels in myelinated nerve fibersNeuroscience · 1996
    • Clinical observations on 3,009 cases of ciguatera (fish poisoning) in the South PacificAmerican Journal of Tropical Medicine and Hygiene · 1979
    • Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among U.S. soldiers in HaitiToxicon · 1997
    • Origin and transfer of toxins involved in ciguateraComparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · 1993