Pyrroloquinoline Quinone (PQQ): a novel approach to managing chronic inflammatory response syndrome and mitochondrial dysfunction
Abstract
Chronic Inflammatory Response Syndrome (CIRS) is a complex, multi-system condition associated with persistent inflammation in response to biotoxins like mould or other environmental triggers. Mitochondrial dysfunction has been implicated in the pathophysiology of CIRS, contributing to chronic inflammation and exacerbating symptoms. Pyrroloquinoline quinone (PQQ), a redox cofactor, has gained attention for its potential neuroprotective, anti-inflammatory, and mitochondria-supporting properties. Additionally, CIRS shares overlapping features with cytokine storm effects observed in COVID infection, long COVID, and potential inflammatory reactions related to mRNA vaccine administration. This letter explores the role of PQQ in managing CIRS and addressing mitochondrial dysfunction caused by multiple potential triggers. However, further research is needed to confirm the effectiveness and safety of PQQ in addressing CIRS and related conditions.
Symptom Clusters
References (10)
- Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern?International Journal of Molecular Sciences · 2021
- Prevalence, Risk Factors and Impacts Related to Mould-Affected Housing: An Australian Integrative ReviewInternational Journal of Environmental Research and Public Health · 2022
- Newer Molecular Methods Bring New Insights into Human- And Building-Health Risk Assessments from Water-Damaged Buildings: Defining Exposure and Reactivity, the Two Sides of Causation of CIRS-WDB IllnessMedical Research Archives · 2021
- Exposure to Actinobacteria resident in water-damaged buildings and resultant immune injury in Chronic Inflammatory Response SyndromeMedical Research Archives · 2021
- Pathophysiological aspects of exposure to dampness-associated indoor mould and mycotoxins: A mini-overviewJournal of Hazardous Materials Advances · 2023
- Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxinBMC Medical Genomics · 2015
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