The plasticity and stability of regulatory T cells
Abstract
Regulatory T (TReg) cells are crucial for the prevention of fatal autoimmunity in mice and humans. Forkhead box P3 (FOXP3)(+) TReg cells are produced in the thymus and are also generated from conventional CD4(+) T cells in peripheral sites. It has been suggested that FOXP3(+) TReg cells might become unstable under certain inflammatory conditions and might adopt a phenotype that is more characteristic of effector CD4(+) T cells. These suggestions have caused considerable debate in the field and have important implications for the therapeutic use of TReg cells. In this article, Nature Reviews Immunology asks several experts for their views on the plasticity and stability of TReg cells.
Key Biomarkers
Symptom Clusters
Cited By (3)
- The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cellsNature Immunology · 2015
- Allergen immunotherapy for allergic airway diseases: Use lessons from the past to design a brighter futurePharmacology & Therapeutics · 2022
- Allergen immunotherapy for allergic respiratory diseases: Leveraging lessons from the past to guide the futureKompass Neumología · 2022
References (4)
- How regulatory T cells workNature reviews. Immunology · 2009
- Inflammation-driven reprogramming of CD4+Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivoPLoS ONE · 2012
- Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cellsImmunity · 2012
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