An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins

Abstract

A B L O G A B OU T T HE R OL E OF ENVIRON MENTAL TOXINS IN CHR O N I C N E U RO IMMU N E DIS EA SE • Blog • Website • About Effects of Trichothecenes This page lists a small fraction of the peer-reviewed literature on the health effects of trichothecene toxins. Included are sections on the effects on the astrocytes and the blood-brain barrier; on other neurological effects; on immunological effects; and on intestinal effects. Astrocytes & Blood-Brain Barrier Weidner Maria, Hüwel Sabine, Ebert Franziska, Schwerdtle Tanja, Galla Hans- Joachim J., Humpf Hans-Ulrich U.. Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PloS one. 2013;8. Weidner Maria, Lenczyk Marlies, Schwerdt Gerald, Gekle Michael, Humpf Hans- Ulrich U.. Neurotoxic potential and cellular uptake of T-2 toxin in human astrocytes in primary culture. Chemical research in toxicology. 2013;26:347–355. Razafimanjato Helisoa, Benzaria Amal, Taïeb Nadira, et al. The ribotoxin deoxynivalenol affects the viability and functions of glial cells. Glia. 2011;59:1672– 1683. Ravindran Jayaraj, Agrawal Mona, Gupta Nimesh, Rao Lakshmana V.. Alteration of blood brain barrier permeability by T-2 toxin: Role of MMP-9 and inflammatory cytokines. Toxicology. 2011;280:44–52. Karunasena Enusha, Larrañaga Michael D., Simoni Jan S., Douglas David R., Straus David C.. Building-associated neurological damage modeled in human cells: a